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EXPERIMENT INFORMATION

The Effect of Spaceflight on Pituitary Oxytocin and Vasopressin Content (COS 2044-14)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Disturbances in fluid and electrolyte balance have been noted in humans exposed to space flight, as shown by a loss of plasma volume and increased excretion of sodium and potassium. Upon return to Earth these imbalances are quickly corrected with rehydration and increased renin-angiotensin-aldosterone activity. The purpose of these investigations was to measure levels of pituitary oxytocin (OT) and vasopressin (VP) as possible indicators of changes in fluid-electrolyte balance during flight.


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Publications
Keil, L.C. et al.: Pituitary Oxytocin and Vasopressin Content of Rats Flown on Cosmos 2044. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 103-108.

Keil, L.C. et al.: Pituitary Oxytocin and Vasopressin Content of Rats Flown on Cosmos 2044. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S166-S168.

Keywords
Hindlimb
Immobilization
Oxytocin
Pituitary gland
Vasopressins
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Oxytocin, pituitary, rat, Radioimmunoassay
Content, Pituitary hormone per mg protein, rat, Calculation
Content, Protein, pituitary, rat, Assay versus BSA
Content, Vasopressin, pituitary, rat, Radioimmunoassay

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-25
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items