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EXPERIMENT INFORMATION

Biomedical Analyses of Human Exposed to a Long Term Space Flight (Hair)
Principal Investigator
Research Area:
Cell and molecular biology
Radiation biology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
This was the first experiment to examine the effect of long-term exposure in space flight on human hair. Hair matrix cells actively divide in a hair follicle, and they sensitively reflect physical conditions. The hair shaft has an advantage in that it keeps the record of changes in the metabolic condition of a subject caused by the environments he or she has been exposed to. Investigators believed by examining human hair, they could determine stress levels and metabolic conditions of a human caused by the microgravity environment and cosmic radiation. The purpose of this investigation was to study the effects of a long-term exposure in space flight on gene expression and mineral metabolism in human hair.


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Publications
Terada M, Seki M, Takahashi R, Yamada S, Higashibata A, Majima HJ, Sudoh M, Mukai C, and Ishioka N. Effects of a closed space environment on gene expression in hair follicles of astronauts in the International Space Station. PLOS ONE. 2016. March 30; 11(3): e0150801. [DOI]

Keywords
DNA
RNA
Gene expression
Hair follicle

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Angiopoietin-related protein 7 (ANGPTL7)
Cartilage oligomeric matrix protein (COMP)
Cyclin-dependent kinase 1 (CDK1) gene level
Fibroblast growth factor (FGF) 18
Platelet-derived growth factor (PDGF)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 21 10/11/2009 12/01/2009 51 days
Expedition 22 11/30/2009 03/18/2010 109 days
Expedition 25 09/24/2010 11/25/2010 31 days
Expedition 26 11/26/2010 03/16/2011 111 days
Expedition 27 03/14/2011 05/23/2011 70 days
Expedition 28 05/23/2011 09/15/2011 115 days
Expedition 29 09/16/2011 11/21/2011 40 days
Expedition 30 11/14/2011 04/27/2012 166 days
Expedition 31 04/27/2012 07/01/2012 65 days
Expedition 32 07/01/2012 09/16/2012 78 days
Expedition 33 09/16/2012 11/18/2012 63 days
Expedition 34 11/18/2012 03/15/2013 117 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
Japan Aerospace Exploration Agency (JAXA)
Proposal Date
07/01/2009
Proposal Source
International