This study was conducted at the Flight Analogs Research Unit (FARU) located at The University of Texas Medical Branch (UTMB) in Galveston, Texas. Subjects were recruited, screened, and, if approved, placed in a bed rest facility for testing and data collection during 13 days of ambulatory acclimation, 30 days of 6-degree HDT bed rest, and 14 days of ambulatory recovery.
Four male and four female subjects completed the experimental protocol once before, twice during, and once after HDT bed rest. Before administration of the capsule, subjects wore a belt with a battery operated SmartPill® data receiver. The data receiver remained on the subject until the capsule stopped transmitting either due to its excretion from the body or termination of battery power, whichever occurred first. After ingestion, the capsule traveled through the intestines by peristalsis and transmitted data continuously for up to 96 hours. All pertinent data transmitted by the SmartPill® was stored on the data receiver and downloaded to a laptop computer after each data collection session was completed. The data from each session was compiled and analyzed using standard statistical programs (e.g. ANOVA) of analysis.
Results of this technology feasibility study will aid in the validation of a noninvasive diagnostic test for GI physio-pathology associated with space flight environmental conditions. The anticipated outcome will facilitate the identification of prospective changes in GI function leading to a reduction in drug absorption associated with microgravity.
This experiment has concluded. Results will be available once the investigator publishes her findings.
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