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EXPERIMENT INFORMATION

Effect of Microgravity on: II. Metabolic Enzymes, Neurotransmitter Amino Acids, and Neurotransmitter Associated Enzymes in Selected Regions of the Central Nervous System (COS 2044-47)
Research Area:
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Six key metabolic enzymes plus glutaminase and glutamate decarboxylase (GAD), as well as glutamate, aspartate and GABA (gamma-aminobutyric acid), were measured in eleven regions of the hippocampal formation of synchronous, flight, and tail-suspended rats.


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Publications
J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 137-154.

Lowry, O.H. et al.: Effect of Microgravity on: II. Distribution of Selected Enzymes and Amino Acids in the Hippocampal Function. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2.

Keywords
Alcohol oxidoreductases
Amino acids
Aspartic acid
GABA
Glutamic acid
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Citrate synthase (CS), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Gamma-aminobutyric acid (GABA), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Glutamate decarboxylase (GAD), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Glutaminase, glutamate decarboxylase (metabolic), hippocampus, brain, rat, NAD redox (enzyme units)
Activity, enzymic, Glutaminase, hippocampus, brain, rat, Assays (enzyme units)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-26.2
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items