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EXPERIMENT INFORMATION

Growth Hormone Regulation, Synthesis and Secretion in Microgravity: I. Secretion of Growth Hormone (COS 2044-11)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Changes in the musculoskeletal, immune, vascular, and endocrine system of the rat occur as a result of short-term space flight. Since pituitary growth hormone (GH) plays a role in the control of these systems, and since an earlier space flight (Spacelab-3) showed that GH cell function was compromised in a number of postflight tests, the Spacelab experiment was repeated and extended in two subsequent flights: Cosmos 1887 and Cosmos 2044, the latter including a tail-suspension control model.


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Publications
Grindeland, R.E. et al.: Growth Hormone Regulation, Synthesis and Secretion in Microgravity: I. Growth Hormone Regulation Synthesis and Secretion in Microgravity. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 157-171.

Hymer, W.C. et al.: Effects of Spaceflight on Rat Pituitary Cell Function. Journal of Applied Physiology, supl.,
vol. 73, no. 2, 1992, pp. S151-S157.

Keywords
Pituitary gland
Prolactin
Somatotropin
Cells, cultured
Cell transplantation

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Growth hormone (GH), pituitary, rat, Histochemistry, fluorescence, cell culture, radioimmunoassay
Content, Interleukin-2 receptor, pituitary, rat
Content, Prolactin (PRL), pituitary, rat, Histochemistry, fluorescence, cell culture, radioimmunoassay
Morphology, Growth hormone cell, pituitary, rat, Light microscopy (descriptive)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-27.1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items