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EXPERIMENT INFORMATION

Antigen-Specific CD4+ T Cell Priming and Memory Response During Spaceflight (ARC00XX19)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: B6.SJL-Ptprca Pepcb/BoyJ

Description
OBJECTIVES:

The experiment tested whether initial specific activation of T cells is intact and whether memory T cell function is maintained during space flight to determine resistance to infections and acquired immune responses.


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Publications
Hughes-Fulford, M., Meissler, J., Aguayo, E. T., Globus, R., Aguado, J., and Candelario, T. (2012) Hyperoxia Inhibits T Cell Activation in Mice. NASA Human Research Program Investigators' Workshop, Houston, TX, February 14-16, 2012, Abstract 4136.

Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. "Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines." FASEB J. 2015 Jun 17. pii: fj.15-275073. pubmed.gov

Hughes-Fulford M, Chang TT, Martinez EM, Li CF. Spaceflight alters expression of microRNA during T-cell activation. FASEB J. 2015 Aug 14. pubmed.gov

Martinez EM, Yoshida MC, Candelario TL, Hughes-Fulford M. "Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation." Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15;308(6):R480-8. pubmed.gov

Keywords
Bacteria
Gene expression
Interferons
Interleukin-1
Interleukin-17
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NASA GeneLab Data

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-131 04/05/2010 04/20/2010 15 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source