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EXPERIMENT INFORMATION

Morphological and Biochemical Examination of Heart Tissue: I. Ultra- structural Alterations in Rat Hearts After Cosmos 2044 Compared to Cosmos 1887 (COS 2044-16)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Previous studies have concluded that when rats undergo a change from the weightless environment of space to Earth gravity, the heart experiences an increase in load compared to weightlessness, manifesting in tissue anoxia and concomitant mitochondrial disorganization. One investigation of this sort flew on Cosmos 1887. This experiment repeats that study.


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Publications
Philpott, D.E. et al.: A Promising Drug for Prevention of Heart Deconditioning During Weightlessness in Rats. Proceedings of Electron Microscope Society, vol. 46, 1988, pp. 130-131.

Philpott, D.E. et al.: Morphological and Biochemical Examination of Heart Tissue: I. Ultrastructural Alterations in Rat Hearts After Cosmos 2044 Compared to Cosmos 1887. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 383-399.

Philpott, D.E. et al.: Ultrastructural and Cellular Mechanisms in Myocardial Deconditioning in Weightlessness. Advances in Space Biology and Medicine, S.L. Bonting, ed., vol. 2, 1992, pp. 83-112.

Keywords
Glycogen
Heart
Heart ventricle
Lipids
Mitochondria, heart
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Mitochondria, atrial myofiber, heart, rat, Electron micrography
Density, Mitochondria, heart, rat, Electron microscopy, film (counts per volume)
Glycogen: atrial myofiber
Lipid accumulation: myocardium
Morphology, Capillaries, myocardium, ventricle, heart, rat, Electron microscopy (descriptive)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-2.1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items