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EXPERIMENT INFORMATION

Morphological and Biochemical Examination of Heart Tissue: III. Cyclic AMP Receptor Protein Distribution in Heart Muscle of Rats Flown on Cosmos 2044 (COS 2044-44)
Principal Investigator
Research Area:
Cardiovascular physiology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The effect of space travel on the cardiovascular system has been investigated to determine if measurable changes could be noted, and if such changes might influence the health of the individual. The present study was undertaken in order to gain insight into a specific biochemical mechanism which may be associated with cardiac changes that experimental animals undergo as a consequence of travel in space, the mechanism in question being cyclic AMP-receptor reactions in the cell particulate fraction.


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Publications
Mednieks, M.I. et al.: Morphological and Biochemical Examination of Heart Tissue: III. Cyclic AMP Receptor Protein Distribution in Heart Muscle of Rats Flown on Cosmos 2044. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 433-452.

Mednieks, M.I. et al.: Photoaffinity Labeling of Regulatory Subunits of Protein Kinase A in Cardiac Cell Fractions of Rats. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S101-S106.

Keywords
Carrier proteins
Cyclic AMP (cAMP)
Cyclic AMP (cAMP) -dependent protein kinases
Cyclic AMP (cAMP) receptor protein
Enzyme inhibitors
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Protein, myocardium, ventricle, heart, rat, Biochemistry
Cyclic AMP (cAMP): myocardium
Distribution, Protein pattern, myocardium, ventricle, heart, rat, Gel Electrophoresis
Morphology, Myocardium, auricle, heart, rat, Light microscopy, computer assisted metrics (area, volume, density)
Morphology, Myocardium, heart, rat, Microscopy (descriptive)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-2.3
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items