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EXPERIMENT INFORMATION

Effect of Spaceflight on Level and Function of Immune Cells: I. Immunology Studies (COS 2044-35)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The purpose of the immunology studies was to continue the systematic attempt to define the range of immunological parameters affected by space flight. The experiments were designed to allow repetition and expansion of studies from a previous flight (Cosmos 1887), with the addition of an antiorthostatic suspension study for direct comparison with space flight effects.


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Publications
Chapes, S.K. et al.: Antiorthostatic Suspension as a Model for the Effects of Spaceflight on the Immune System. Journal of Leukocyte Biology, vol. 53, no. 3, 1993, pp. 227-235.

Kontstantinova, I.V. et al.: Results of Immunological Experiments Aboard the Cosmos Biosatellites and Problems in Space Immunology. Physiologist, supl., vol. 35, no. 1, 1992, pp. S220-S221.

Lesnyak, A.T. et al.: Immune Changes in Test Animals During Spaceflight. Journal of Leukocyte Biology, vol. 54, no. 3, 1993, pp. 214-226.

Rykova, M.P. et al.: Effect of Spaceflight on Natural Killer Cell Activity. Journal of Applied Physiology, supl.,
vol. 73, no. 2, 1992, pp. S196-S200.

Sonnenfeld, G. et al.: Effect of Spaceflight on Immune Responses: Bone Marrow Cell Response to Colony Stimulating Factor and Leukocyte Subsets. Physiologist, supl., vol. 35, no. 1, 1992, pp. S222-S223.

Sonnenfeld, G. et al.: Effect of Spaceflight on Level and Function of Immune Cells: I. Immunology Studies. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 195-206.

Sonnenfeld, G. et al.: Spaceflight Alters Immune Cell Function and Distribution. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S191-S195.

Keywords
Antigens
Bone marrow
Granulocyte-macrophage colony-stimulating factor
Immune system
Spleen
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Leukocytes, white cells, bone marrow, rat, Clinical laboratory
Count, Leukocytes, white cells, spleen, rat, Clinical laboratory
Count, T-helper cells, bone marrow, rat, Surface markers, microscopy
Count, T-helper cells, spleen, rat, Surface markers, microscopy
Count, T-pan cells, bone marrow, rat, Surface markers, microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-4.1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items