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EXPERIMENT INFORMATION

Bone Biochemistry and Mineral Distribution in the Femurs of Rats after Two Weeks in Space: Circulating Parathyroid Hormone, Calcitonin, and Osteocalcin (COS 2044-9)
Principal Investigator
Research Area:
Bone and calcium physiology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The functional state of the parathyroid gland and the calcitonin cells of the thyroid is critical to the alterations in calcium and bone metabolism during space flight because of the major role each hormone has in their regulation. The purpose of this experiment was to document the early postflight levels of two calcium regulating hormones. Postflight evidence for impaired calcium homeostasis from exposure to space flight as well as the status of these hormones was reported.


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Publications
Arnaud, S.B. et al.: Bone Biochemistry Mineral Distribution and Calcium Regulating Hormones in Rats After the Cosmos 2044 Biosatellite Flight: I. Circulating Parathyroid Hormone and Calcitonin in Rats after Spaceflight. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 69-101.

Arnaud, S.B. et al.: Circulating Parathyroid Hormone and Calcitonin in Rats After Spaceflight. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S169-S173.

Keywords
Adrenal glands
Aging
Calcitonin
Creatinine
Homeostasis
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Calcitonin, plasma, rat, Radioimmunoassay
Content, Calcium, femur, bone, rat, Automated analyzer
Content, Calcium, femur, bone, rat, X-ray microtomography
Content, Calcium, total, plasma, rat, Automated analyzer
Content, Collagen crosslinks, femur, rat, Biochemical analysis
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-8
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items