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Gravity and Skeletal Growth: I. Gravity and Skeletal Growth (COS 2044-15)
Principal Investigator
Research Area:
Skeletal physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Experiments flown on Cosmos 1887 were complicated by unexpected postflight processing delays. To differentiate between flight response with minimal recovery time and flight response with extended recovery superimposed, this experiment was repeated with the addition of a tail-suspended model as a control group. Data from this study are difficult to compare with that from Cosmos 1887 due to a 25-day age difference; the larger bones of these animals agree with the older age of the rats.

This study was undertaken to investigate whether space flight would change the amount of collagenase detectable in the calvaria of adult rats. It was postulated that the change in blood flow and load bearing connected with weightlessness would change the amount and distribution of collagenase in calvaria. Thus immunohistochemical staining for collagenase was performed on sections of each calvaria as well as a morphological assessment.

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Morey-Holton, E.R.: Gravity and Skeletal Growth: I. Gravity and Skeletal Growth. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 189-192.

Bone development
Bone remodeling
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, enzymic, Collagenase, calvarium, bone, rat, Immunohistochemical (amount, distribution)
Area, Bone, tibia, rat, Microscopy
Area, Marrow, calvaria, bone, rat, Microscopy
Area, Marrow, tibia, bone, rat, Microscopy
Bone matrix: calvaria
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items