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Gravity and Skeletal Growth: III. Recovery of Osteogenic Potential (COS 2044-6)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Data from previous space flight missions suggest an initial inhibition of osteoblast histogenesis followed by a postflight recovery response. This study of rat maxillary molar periodontal ligament (PDL) allowed further investigation of the osteoblast histogenesis recovery pattern.

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Garetto, L.P. et al.: Gravity and Skeltal Growth: III. Preosteoblast Production in Cosmos 2044 Rats: Short Term Recovery of Osteogenic Potential. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 201-212.

Garetto, L.P. et al.: Nuclear Volume Analysis of Osteoblast Histogenesis in the Rat Tibial Metaphysis During Simulated Weightlessness. Fundamentals of Bone Growth, A.D. Dixon, B.G. Sarnat, and D.A.N. Hoyte, eds., 1991, pp. 397-405.

Garetto, L.P. et al.: Preosteoblast Production in Cosmos 2044 Rats - Short-Term of Osteogenic Potential. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S14-S18.

Cell division
Cell nucleus
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Count, Osteoblast, periodontal ligament (PDL), rat, Histology, microscopy
Count, Osteoprogenitors, periodontal ligament (PDL), rat, Histology, microscopy
Count, Precursor cells, periodontal ligament (PDL), rat, Histology, microscopy
Count, Preosteoblasts, periodontal ligament (PDL), rat, Histology, microscopy
Formation, Bone, maxillea, rat, Morphometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items