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EXPERIMENT INFORMATION

Mineral Distribution and Balance in Rats During Spaceflight (COS 2044-30)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Previous studies of mineral distribution and homeostasis have shown significant effects of space flight on the mineral composition of bones and the handling of major trace minerals by the intestine. Data from Cosmos 1129 and 1887 have shown a significant increase in fecal ash, predominantly due to progressive increases of excreted sodium and potassium, and to a lessor extent calcium. Analyses of vertebrae from Cosmos 1887 further suggested that flight bones were more highly mineralized, consistent with other space flight studies. This experiment was primarily to add supplementary and supporting data to these findings, especially for the excreta analyses where measurements were made from pooled samples.


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Publications
Cann, C. et al.: Mineral Distribution and Balance in Rats During Spaceflight. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 225-233.

Keywords
Bone and bones
Bone density
Feces
Intestinal mucosa
Lumbar vertebrae
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Composition, Diet, rat, Cosmos
Content, Calcium, in feces, rat, Atomic absorption spectrophotometry, isotope dilution
Content, Calcium, vertebra, bone, rat, Atomic absorption spectrophotometry
Content, Calcium, vertebra, bone, rat, Microprobe, crystal sensors
Content, Copper, in feces, rat, Atomic absorption spectrophotometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-10
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items