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EXPERIMENT INFORMATION

The Effects of Microgravity on the Tissue Regenerative Potential of Stem Cells - Space Tissue Loss Stem Cell Regeneration (STL-SCR) (ARC00XX44)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Species: Mouse

Description
OBJECTIVES:

The work we proposed here is centered on the specific hypothesis that somatic stem cells responsible for tissue regeneration may require the mechanical stimulation of gravity to proliferate and differentiate, and to regenerate tissues at normal rates, and that therefore, exposure to microgravity may slow down tissue regenerative processes based on adult stem cell progenitors. Our results from spaceflight experiments with amphibian (newt) tail regeneration during the Foton M2 and Foton M3 missions, suggests that spaceflight significantly retards tissue regeneration by interfering with newt tail blastema stem cell progenitor proliferation and differentiation. These findings suggest that normal long-term homeostatic tissue regenerative processes in mammals may also be sensitive to the absence of gravity-generated forces in space, and that this may cause tissue degeneration. In this study we sought to gather further evidence about the role of gravity-generated forces in promoting tissue regeneration and the molecular mechanisms by which gravity in stem cells is translated into proliferation and differentiation.


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Publications
Blaber Elizabeth, Sato Kevin, and Almeida Eduardo A.C.. Stem Cells and Development. December 2014, 23(S1): 73-78. pubmed.gov

Keywords
Bioreactor
Wound healing
Weightlessness
Embryoid bodies
Pluripotent stem cells

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

NASA GeneLab Data

Parameters
Expression, gene, Differentiation markers, embryonic stem cells, embryoid bodies, mouse, Quantitative real-time PCR (qRT-PCR)
Expression, gene, Stem cell markers, embryonic stem cells, embryonic bodies, mouse, Quantitative real-time PCR (qRT-PCR)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-131 04/05/2010 04/20/2010 15 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
Hardware Items