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EXPERIMENT INFORMATION

Effect of Spaceflight on Level and Function of Immune Cells: II. Proliferation and Cytokines (COS 2044-18)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The purpose of the immunology studies was to continue the systematic attempt to define the range of immunological parameters affected by space flight. The experiments were designed to allow repetition and expansion of studies from a previous flight (Cosmos 1887), with the addition of an antiorthostatic suspension study for direct comparison with space flight effects.

There is ample evidence from the study of human peripheral blood lymphocytes following space flight that many astronauts have an impairment of mitogen-induced T-cell proliferation. Cosmos 2044 afforded the first opportunity to study space flight effects on the proliferation of T-cells and B-cells from rat lymph nodes. The study was also designed to investigate potential mechanisms involved in any absorbed T-cell deficiency.


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Publications
Nash, P.V. et al.: Effect of Hindlimb Suspension Simulation of Microgravity on In Vitro Immunological Responses. Experimental Cell Research, vol. 195, 1991, pp. 353-360.

Nash, P.V. et al.: Effect of Spaceflight on Level and Function of Immune Cells: II. Proliferation and Cytokines. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 207-219.

Nash, P.V. et al.: Effect of Spaceflight on Lymphocyte Proliferation and Interleukin-2 Function. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S186-S190.

Keywords
Cytokines
DNA
Interleukin-1
Interleukin-2
Interleukin-3
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, Cell proliferation, bone marrow, rat, Colony stimulating factor-granulocyte/monocyte (CSF-GM), microscopy
Cell proliferation: lymphocytes
Cell proliferation: spleen
Interleukin-2 production
Response, Immune, bone marrow, cell surface markers, to fluorescein-labeled antibodies, rat, Flow cytometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-4.2
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items