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EXPERIMENT INFORMATION

Risk of Intervertebral Disc Damage after Prolonged Space Flight (NNX10AM18G)
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The goal of this research is to comprehensively characterize space-flight induced changes in disc morphology, biochemistry, metabolism, and kinematics. These data will be correlated with measures of back pain intensity and disability. The hypothesis is that spontaneous space-flight back pain and disc herniation are due to biomechanical and biological pathomechanisms. First, microgravity leads to higher than normal physiologic disc swelling and increased disc height that may stiffen the lumbar motion segment and cause abnormal segmental movement patterns. These biomechanical changes increase risk for annular rupture, vertebral endplate microfracture, and facet joint capsule strain. Second, increased disc swelling may alter nuclear matrix osmotic pressure and nutrient transport from endplate capillaries in adjacent vertebra. These biological changes adversely affect disc cell metabolism, causing pain and inducing disc matrix degradation.


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Publications
Mao CP, Macias BR, and Hargens AR. Shoulder skin and muscle hemodynamics during backpack carriage. Applied Ergonomics. 2015. November; 51:80-4. [pubmed.gov]

Sayson JV, Lotz J, Parazynski S, Hargens AR. Back pain in space and post-flight spine injury: Mechanisms and countermeasure development. Acta Astronautica 2013; 86: 24-38.

http://www.nature.com/articles/npjmgrav201622

Keywords
Intervertebral disk

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
Back pain
Back pain
Disc biochemistry
Disc kinematics
Disc metabolism
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 33 09/16/2012 11/18/2012 63 days
Expedition 35 03/15/2013 05/13/2013 58 days
Expedition 36 05/13/2013 09/10/2013 166 days
Expedition 37 09/10/2013 11/10/2013 61 days
Expedition 39 03/10/2014 05/13/2014 64 days
Expedition 40 05/13/2014 09/10/2014 133 days
Expedition 41 09/10/2014 11/09/2014 29 days
Expedition 42 11/10/2014 03/11/2015 121 days
Expedition 43 03/11/2015 06/10/2015 91 days
Expedition 44 06/10/2015 09/11/2015 93 days
Expedition 45 09/11/2015 12/11/2015 91 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
07/01/2010
Proposal Source
2009 Crew Health NNJ09ZSA002N