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EXPERIMENT INFORMATION

Longitudinal Study of Astronaut Health (LSAH)
Research Area:
Clinical medicine
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The Longitudinal Study of Astronaut Health (LSAH) was a research study examining the incidence of acute and chronic morbidity and mortality of astronauts and describe the risks associated with the astronauts' occupational exposures, as compared to the risks for a matched control population, civil service employees at Johnson Space Center (JSC). This study was conducted between 1989 and 2010 and has been closed out. However data from this study may be available to approved investigators. Publications utilizing these data continue to be written and are being added to this record below.


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Publications
Bagian JP, Ward DF. A retrospective study of promethazine and its failure to produce the expected incidence of sedation during space flight. J Clin Pharmacol 1994;34(6):649-651. [pubmed.gov]

Baker E, Barratt MR, Wear M. Human Response to Spaceflight. In Principles of Clinical Medicine for Space Flight, Chapter 2. Edited by Barratt MR and Pool SL. Springer Science, Inc, New York. 2008.

Billica RD, Simmons SC, Mathes KL, McKinley BA, Chuang CC, Wear ML, and Hamm PB. Perception of the medical risk of spaceflight. Aviation, Space and Environmental Medicine. 1996;67:467-473.[pubmed.gov]

Cucinotta FA, Manuel FK, Jones J, Iszard G, Murray JD, Djojonegoro BM and Wear ML. Space Radiation and Cataracts in Astronauts. Radiation Research 2001;156(5):460-466. [Erratum in: Radiation Research 2001 Dec;156(6):811][pubmed.gov]

Hamilton DR, Murray JD, and Ball CG. Cardiac health for astronauts: coronary calcification scores and CRP as criteria for selection and retention. Aviation, Space & Environmental Medicine. 2006 Apr;77(4):377-87.[pubmed.gov]

Hamilton DR, Murray JD, Kapoor D, and Kirkpatrick AW. Cardiac health for astronauts: current selection standards and their limitations. Aviation, Space & Environmental Medicine 2005 Jul;76(7):615-26. Review.[pubmed.gov]

Hamm PB, Billica RD, Johnson GS, Wear ML, Pool SL. Risk of cancer mortality among the longitudinal study of astronaut health (LSAH) participants. Aviat Space Environ Med 1998;69(2):142-144. [pubmed.gov]

Hamm PB, Nicogossian AE, Pool SL, Wear ML, and Billica RD. Design and Current Status of the Longitudinal Study of Astronaut Health. Aviation, Space and Environmental Medicine. 2000;71(6):564-570.[pubmed.gov]

Jennings RT, Davis JR, Santy PA. Comparison of aerobic fitness and space motion sickness during the shuttle program. Aviat Space Environ Med 1988;59(5):448-451. [pubmed.gov]

Jones JA, McCarten M, Manuel K, Djojonegoro B, Murray J, Feiverson A, Wear M. Cataract formation mechanisms and risk in aviation and space crews. Aviation, Space & Environmental Medicine 2007; 78(4,Suppl.):A56–A66.[pubmed.gov]

Longnecker DE, Manning FJ, and Worth MH, Editors. Review of NASA’S Longitudinal Study of Astronaut Health. Committee on the Longitudinal Study of Astronaut Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies. National Academies Press, Washington, D.C., 2004.

Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, Tarver WJ, Dervay JP, Hamilton DR, Sargsyan A, Phillips JL, Tran D, Lipsky W, Choi J, Stern C, Kuyumjian R, Polk JD. Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight. Ophthalmology. 2011 Aug 17. [pubmed.gov]

McMonigal KA; Braverman LE; Dunn JT; Stanbury JB; Wear ML; Hamm PB; Sauer RL; Billica RD; and Pool SL. Thyroid Function Changes Related to Use of Iodinated Water in the U.S. Space Program. Aviation, Space and Environmental Medicine. 2000;71(11):1120-1125[pubmed.gov]

Peterson LE, Pepper LJ, Hamm PB and Gilbert SL. Longitudinal Study of Astronaut Health: Mortality in the years 1959-1991. Radiation Research. 1993;133:257-264.[pubmed.gov]

Pietrzyk RA, Jones JA, Sams CF, Whitson PA. Renal stone formation among astronauts. Aviat Space Environ Med 2007 Apr;78(4 Suppl):A9-A13. [pubmed.gov]

Putcha L, Berens KL, Marshburn TH, Ortega HJ, Billica RD. Pharmaceutical use by U.S. astronauts on space shuttle missions. Aviat Space Environ Med 1999;70(7):705-8. [pubmed.gov]

Scheuring, Richard A; Mathers, Charles H; Jones, Jeffrey A; Wear, Mary L. Musculoskeletal Injuries and Minor Trauma in Space: Incidence and Injury Mechanisms in U.S. Astronauts. Aviation, Space & Environmental Medicine. 2009 Feb;80(2):117-124.[pubmed.gov]

View Other Presentations and Analyses:

  • Amirian E, Clark A, Halm M, Hartnett HJ. An Update on Mortality in the U.S. Astronaut corps: 1959-2009. Presented at the American Public Health Association Annual Meeting, November 2009.
  • Baisden DL, Effenhauser RK, and Wear ML. Inflight medical events in the Shuttle program. Presented at the 71st Annual Scientific Meeting of the Aerospace Medical Association, May 2000.
  • Barratt MR, Houser SA, and Wear ML. Operational monitoring of pre- and post-flight blood parameters for first time shuttle-flyers. Presented at the 68th Meeting of the Aerospace Medical Association, May 1997. Abstract published in Aviation, Space, and Environmental Medicine. 1997;68(7):618.
  • Clark A, Hartnett HJ, Amirian E. Spaceflight and Cancer Risk in the U.S. Astronaut Corps: 1959-2010. To Be Presented at Aerospace Medical Association 82nd Annual Scientific Meeting, May 8-12, 2011.
  • Eudy DA, Parisian D, Rodriguez S and Wear ML. CyberCafe demonstration of SNOMED coding techniques. SNOMED Users Group, September 2003.
  • Halm MK, Clark A, Wear ML, Murray JD, Polk JD, Amirian E. Traditional Cardiovascular Risk Factors as Predictors of Cardiovascular Events in the U.S. Astronaut Corps. Presented at the Kelsey Research Foundation 10th Annual Health Services and Outcomes Research Conference. Houston, Texas. December 2009.
  • Jones JA. Urolithiasis in Space. 2nd International Urolithiasis Research Symposium. April 17 - 18, 2008, Indianapolis, Indiana.
  • Johnston SJ, Marshburn TH, and Lindgren K. Predicted incidence of evacuation-level illness/injury during Space Station operation. Presented at the 71st Annual Scientific Meeting of the Aerospace Medical Association, May 2000.
  • Johnston SL, Wear ML, and Hamm PB. Incidence of herniated nucleus pulposis among astronauts and other selected populations. Presented at the 69th Meeting of the Aerospace Medical Association, May 1998.
  • Jones JA, Sargsyan A, Pietryzk R, Sams C, Stepaniak P, and Whitson P. Urolithiasis and Genitourinary Systems Issues for Spaceflight. 2nd International Urolithiasis Research Symposium. April 17 - 18, 2008, Indianapolis, Indiana.
  • Kerstman EL, Minard CG, Freire de Carvalho MH, Walton ME, Myers JG, Saile LG, Lopez V, Butler DJ, Johnson-Throop KA. Validation of the Integrated Medical Model Using Historical Space Flight Data. Proceedings of the Winter Simulation Conference, December 2010.
  • Manuel FK. Vision aspects of space flight. Presented at the 71st Annual Scientific Meeting of the Aerospace Medical Association, May 2000.
  • Minard CG, Freire de Carvalho MH, Iyengar MS. Optimizing Medical Kits for Space Flight. Proceedings of the Winter Simulation Conference, December 2010.
  • Scheuring RA, Mathers CH, Jones JA, Wear ML, Djojonegoro B. In-flight Musculoskeletal Injuries and Minor Trauma in the U.S. Space Program: A Comprehensive Summary of Occurrence and Injury Mechanism. Presented at Aerospace Medical Association Annual Scientific Meeting, May 2008.
  • Thomas MM, McGinnis PJ, McCulley PA, Billica RD, and Wear ML. Building an EMR on an Epidemiological Foundation. Presented at Smart Systems 2000 Conference, Houston, TX. September 2000.
  • Wear ML. Lifetime Surveillance of Astronaut Health. Presented at Innovation 2010, Johnson Space Center, April 28, 2010.
  • Wear ML and Eudy DA. The Longitudinal Study of Astronaut Health. Presented at a Quarterly meeting of the Houston Area Health Information Management Association, June 26, 2003.
  • Wear ML, Johnson KA, Krog RL, Eudy DA, Rogers J. SNOMED CT: Out of This World with NASA. Presented at the 4th Annual SNOMED International Users Group, November 2002.
  • Wear ML, Marshburn T, and Billica RD. Medical Risk Assessment for Mars Missions. Presented at the 71st Annual Scientific Meeting of the Aerospace Medical Association, May 2000. Also presented at Smart Systems 2000 Conference, Houston, TX. September 2000.
  • Wear ML, Pepper LJ, Hamm PB, Pool SL, and Billica RD. The Longitudinal Study of Astronaut Health. Panel presentation on "Medical Informatics and the U.S. Space Program" at the 17th Annual Symposium on Computer Applications in Medical Care, October 30-November 1, 1993, Washington, DC.

  • Keywords
    Longitudinal studies
    Cohort studies

    Data Information
    Data Availability
    Archiving in progress. Data is not yet available for this experiment.

    Mission/Study Information
    Mission Launch/Start Date Landing/End Date Duration
    LSAH 01/01/1989 05/31/2010 21 years

    Additional Information
    Managing NASA Center
    Johnson Space Center (JSC)
    Responsible NASA Representative
    Johnson Space Center LSDA Office
    Project Manager: Pamela A. Bieri
    Institutional Support
    National Aeronautics and Space Administration (NASA)
    Similar Experiments or Analyses
    Links