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EXPERIMENT INFORMATION

Alternative Compression Garment (Flight Analog) (BEDREST_ACG)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The overall objective of this study was to improve upon existing suit designs by developing an elastic, gradient compression garment that would provide a continuous compression from the feet to the abdomen. Additionally, to develop a doffing protocol that enables the use of compression garments after simulated space flight to prevent hypotensive events without prolonging the recovery period.

Specific Aim I: To determine whether subjects wearing breast-high, graded compression garments developed symptoms of orthostatic intolerance after 14 days of head-down tilt bed rest (Groups 1 and 2).
Specific Aim II: To determine the time course of cardiovascular readaptation during the first three days of post-bed rest recovery after using compression garments for a short period of time on BR+0 (Group 1).
Specific Aim III: To determine the effect of wearing graded compression garments on BR+0, with reduced compression on subsequent days, on the time course of cardiovascular readaptation during the first three days of post-bed rest recovery (Group 2).


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Publications
Lee SM, Guined JR, Brown AK, Stenger MB, Platts SH. Metabolic consequences of garments worn to protect against post-spaceflight orthostatic intolerance. Aviation, Space, and Environmental Medicine. 2011. June; 82(6):648-53. [pubmed.gov]

Platts SH, Tuxhorn JA, Ribeiro LC, Stenger MB, Lee SM and Meck JV. Compression garments as countermeasures to orthostatic intolerance. Aviation, Space, and Environmental Medicine. 2009. 80: 437-442. [pubmed.gov]

Stenger MB, Lee SM, Ribeiro LC, Phillips TR, Ploutz-Snyder RJ, Willig MC, Westby CM, and Platts SH. Gradient compression garments protect against orthostatic intolerance during recovery from bed rest. European Journal of Applied Physiology. 2013, Dec 14. [pubmed.gov]

Stenger, M. B., Brown, A. K., Lee, S. M. C., Locke, J. P, and Platts, S. H. Gradient compression garments as a countermeasure to post-spaceflight orthostatic intolerance. Aviation, Space, and Environmental Medicine. 2010. September; 81(9):883-7. [pubmed.gov]

Keywords
Cardiovascular physiology
Plasma volume
Echocardiography
Orthostatic intolerance

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Data Information
Data Availability
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Parameters
Blood volume
Carboxyhemoglobin
Cardiovascular readaptation
Continuous compression
Echocardiography
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 17 05/11/2011 02/12/2012 278 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
DirectedResearch