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EXPERIMENT INFORMATION

Integrated Resistance and Aerobic Training Study (BEDREST_iRATS)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Campaign 11 will utilize 70 days of six degrees head-down bed rest. The study will consist of 13 days of pre bed rest for the non-exercise group and 21 days of pre bed rest for the exercise group, as well as 14 days of post bed rest. Head-down tilt bed rest relieves longitudinal gravitational loading of the cardiovascular, bone, and muscle systems. Healthy subjects exposed to prolonged bed rest experience some of the adaptive physiological responses and associated deconditioning seen in astronauts exposed to prolonged weightlessness. Campaign 11 will consist of the integration of standard measures and visual monitoring with investigator study protocols.

The objective of the Integrated Resistance and Aerobic Training (iRATS) is for subjects to perform six days per week of exercise training that consists of a combination of high intensity resistance and aerobic exercise in order to maintain cardiovascular fitness and muscular strength and function during bed rest.
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Publications
Ploutz-Snyder LL, Downs M, Ryder J, Hackney K, Scott J, Buxton R, Goetchius E, and Crowell B. Integrated resistance and aerobic exercise protects fitness during bed rest. Medicne and Science in Sports and Exercise. 2014. February; 46(2):358-68. [pubmed.gov]

Keywords
Exercise
Magnetic resonance imaging (MRI)
Musculoskeletal physiology
Oxygen consumption
Ultrasonography

Photo Gallery
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Data Information
Data Availability
Archiving in Progress. Some restricted access data exist for this experiment.
Data Sets+ Request data

Parameters
Actin filament density
Cross Sectional Area leg
Dystrophin dystroglycan complex
Fiber ATPase
Fiber cross bridge stiffness
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 11 05/11/2011 12/15/2014 3 years, 7 months, 4 days
iRATS14 11/09/2010 04/27/2011 160 days

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
11/01/2010