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EXPERIMENT INFORMATION

Physiological Factors Contributing to Post Bed Rest Changes in Functional Performance (Functional Task Test) (BEDREST_FTT)
Principal Investigator
Research Area:
Cardiovascular physiology
Muscle physiology
Neurophysiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Prolonged exposure to space flight conditions results in a battery of physiological changes, some of which contribute to sensorimotor and neurovestibular deficits. The objective of this study was to identify the key underlying physiological factors that contribute to performance changes in functional tests that are representative of critical mission tasks for planetary operations. Subjects were tested on an integrated suite of functional and physiological tests before and after 70 days of bed rest. Subjects completed 13 days of pre bed rest testing for the non-exercise group and 21 days of pre bed rest testing for the exercise group, as well as 14 days of post bed rest testing.

This study had the following specific aims:

  1. Identify the critical mission tasks that may be impacted by alterations in physiological responses.
  2. Map physiological changes to alterations in functional performance.
  3. Aid in the design of countermeasures that specifically target the physiological systems responsible for impaired functional performance.


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Publications
Madansingh S. and Bloomberg JJ. Understanding the effects of spaceflight on head–trunk coordination during walking and obstacle avoidance. Acta Astronautica. 2015. October-November; 115:165-72. [DOI]

Mulavara AP, Peters BT, Miller CA, Kofman IS, Reschke MF, Taylor LC, Lawrence EL, Wood SJ, Laurie SS, Lee SMC, Buxton RE, May-Phillips TR, Stenger MB, Ploutz-Snyder LL, Ryder JW, Feiveson AH, and Bloomberg JJ. Physiological and functional alterations after spaceflight and bed rest. Medicine and Science in Sports and Exercise. 2018. September; 50(9):1961-80. pubmed.gov

Miller CA, Kofman IS, Brady RR, May-Phillips TR, Batson CD, Lawrence EL, Taylor LC, Peters BT, Mulavara AP, Feiveson AH, Reschke MF, and Bloomberg JJ. Functional task and balance performance in bed rest subjects and astronauts. Aerospace Medicine and Human Performance. 2018. September; 89(9):805-15. pubmed.gov

Keywords
Ataxia
Cardiovascular deconditioning
Muscular atrophy
Bed rest
Task performance and analysis

Parameters
Activity board time
Blood volume
Diastolic blood pressure, difference
Diastolic blood pressure, fall recovery prone
Diastolic blood pressure, stand
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 11 05/11/2011 12/15/2014 3 years, 7 months, 4 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
04/18/2011
Proposal Source