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EXPERIMENT INFORMATION

Mutagenic Effectiveness of Known Doses of Gamma Irradiation (P-1037)
Principal Investigator
Research Area:
Cell and molecular biology
Radiation biology
Species Studied
Scientific Name: Neurospora crassa Species: Fungus

Description
Objectives:

An experiment exploring the mutagenic effects of known doses of radiation in combination with microgravity on Neurospora crassa was first flown on the Gemini XI mission, in 1966. In Gemini XI, conidia were tested on both the surface of Millipore filters and in a colloidal suspension of sugar, and a 32P beta- ray radiation source was used. This experiment was to conduct a similar study on the genetic effects of space flight alone and in combination with known doses of radiation, on the surface of Millipore filters, using a 32Sr gamma-ray radiation source.


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Publications
de Serres, F.J. and B.B. Webber: Genetic Effects of 85Sr Irradiation on Neurospora crassa. Radiation Research, vol. 35, 1968, pp. 436-444.

de Serres, F.J. and B.B. Webber: Mutagenic Effectiveness of Known Doses of Radiation in Combination with Zero Gravity on Neurospora. BIOSPEX: Biological Space Experiments, NASA TM-58217, 1979, p. 160.

de Serres, F.J. and B.B. Webber: The Induction of Recessive Lethal Mutations Under Weightlessness in the Neurospora Experiment on the Biosatellite II Mission. Radiation Research, vol. 43, 1970, pp. 452-459.

de Serres, F.J.: Effects of Radiation During Spaceflight on Microorganisms and Plants on the Biosatellite II and Gemini 11 Missions. Life Sciences and Space Research: Proceedings of the 11th Plenary Meeting, Tokyo, Japan, May 14-16, 1968, North Holland Publishing, 1969, pp. 62-66.

de Serres, F.J.: Effects of Weightlessness on Simple Life Forms in Biosatellite II. Federation of American Society for Experimental Biology, 56th Annual Meeting, Atlantic City, N.J., April 9, 1972, Conf-720441, 1972, p. 8.

de Serres, F.J.: Effects of Weightlessness on Simple Life Forms in Biosatellite II. The Physiologist, vol. 16, 1973, pp. 225-228.

de Serres, F.J.: Mutagenic Effectiveness of Known Doses of Radiation in Combination with Zero Gravity on Neurospora crassa. The Experiments of Biosatellite II, NASA SP-204, 1971, pp. 325-331.

de Serres, F.J.: Neurospora Experiment P-1037. Final Report, NASA CR-112355, 1970.

Saunders, J.F. et al.: The Experiments of Biosatellite II. S.A. Gordon and M.J. Cohen, eds., Gravity and the Organism, University of Chicago Press, 1971, pp. 443-450.

Keywords
Abnormalities, radiation-induced
Chromosome aberrations
Chromosome breakage
Chromosome deletion
Chromosomes
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Chromosome breakage
Count, Spore, neurospora crassa, Microscopy
Genetic defects
Growth rate: mold
Mutation rate, lethal-recessive
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Biosatellite II 09/07/1967 09/09/1967 2 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
BIO2-4
Protocol / Approach