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EXPERIMENT INFORMATION

Housing Temperature: An Important Variable for Simulated Spaceflight Studies Using Mice (80NSSC19K0430)
Principal Investigator
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57/B6

Description
OBJECTIVES:
This proposal will explore the individual and combined effects of mild cold stress induced by room temperature housing and hindlimb unloading (HLU) on the skeleton in C57BL6 (B6) mice, a strain commonly used in spaceflight and HLU studies. To accomplish our goal, we propose 2 Specific Aims:

Specific Aim 1: Determine the contribution of increased adaptive thermogenesis to bone loss during HLU in mice housed at room temperature.

Specific Aim 2: Determine the lowest sub-thermoneutral housing temperature able to prevent adaptive thermogenesis-associated bone loss.

Successful completion of the proposed research will provide guidance to investigators for insuring housing conditions minimize the confounding effects of species-specific differences in thermoregulation on experimental outcomes with the ultimate goal of optimizing the mouse to model human responses to spaceflight.


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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
01/31/2019
Proposal Source
2016-17 Space Biology (ROSBio) NNH16ZTT001N-FG