Specific Aim 1: Determine the contribution of increased adaptive thermogenesis to bone loss during HLU in mice housed at room temperature.
Specific Aim 2: Determine the lowest sub-thermoneutral housing temperature able to prevent adaptive thermogenesis-associated bone loss.
Successful completion of the proposed research will provide guidance to investigators for insuring housing conditions minimize the confounding effects of species-specific differences in thermoregulation on experimental outcomes with the ultimate goal of optimizing the mouse to model human responses to spaceflight.
Aim 2: We will accomplish this aim by performing temperature response studies (20-32°C) to evaluate induction of adaptive thermogenesis. Once we identify the lowest sub-thermoneutral housing temperature that does not induce adaptive thermogenesis, we will perform a long-term study to verify that minimal premature bone loss occurs and that magnitude of HLU-induced bone loss does not differ from mice housed at thermoneutral.
This experiment is currently in progress. Results will be available at the conclusion of the study.
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