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The Effect of Long-term Microgravity Exposure on Cardiac Autonomic Function by Analyzing 48-hours Electrocardiogram (Biological_Rhythms48)
Principal Investigator
Research Area:
Cardiovascular physiology
Clinical medicine
Species Studied
Scientific Name: Homo sapiens Species: Human

Biological clocks synchronize and modulate circadian rhythms of systemic organs. Disruption of circadian rhythm are not only associated with an enhanced risk of cardiac disease, but also induce variety of other disease, such as metabolic disorder. Biological clocks are known to be affected by external stimulation, such as light and darkness. However, it is uncertain what influence space environment has on the biological clock. Measurement of RR-interval variability can reflect the circadian rhythm on cardiac autonomic nerve function. The investigators conducted continuous 24-hour RR intervals measurement in ten subjects for on a previous project. The preliminary data showed a variety of changes on biological rhythms and some biological rhythm of subjects were prolonged for 24 hours or more after flight. Therefore, to clarify the change of an accurate biological clock from spaceflight influence, we will evaluate 48-hour HRV (Heart Rate Variablity) and 96-hours of inflight actigraph on the future subjects.

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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Electrocardiogram - ECG

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 32 07/01/2012 09/16/2012 78 days
Expedition 33 09/16/2012 11/18/2012 63 days
Expedition 35 03/15/2013 05/13/2013 58 days
Expedition 36 05/13/2013 09/10/2013 166 days
Expedition 37 09/10/2013 11/10/2013 61 days
Expedition 38 11/10/2013 03/10/2014 120 days
Expedition 40 05/13/2014 09/10/2014 133 days
Expedition 41 09/10/2014 11/09/2014 29 days
Expedition 43 03/11/2015 06/10/2015 91 days
Expedition 44 06/10/2015 09/11/2015 93 days
Expedition 45 09/11/2015 12/11/2015 91 days
Expedition 46 12/11/2015 03/02/2016 82 days
Expedition 47 03/02/2016 06/18/2016 108 days
Expedition 48 06/18/2016 09/06/2016 80 days
Expedition 49 09/06/2016 10/30/2016 54 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
Japan Aerospace Exploration Agency (JAXA)