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EXPERIMENT INFORMATION

Effects of Short Duration Space Flight on Type 1 and 2 Cytokine Balance and Endocrine Regulation (DSO 501)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Stress factors of space flight will affect the immune system in vivo and change the in vitro response to mitogens in the presence of stress hormones such as cortisol. It is thought that chronic stress-sensitization of immunocytes in vivo may result in a higher tolerance of immunocompetent cells to “stress” challenge in vitro, exhausting the immune system and resulting in a deeper suppression ofimmunocyte functions in response to mitogen in cortisol-treated culture.

The purpose of the study was to investigate the effect of space flight on Type1/Type 2-cytokine balance and the role of the neuro-endocrine system in it. The investigation was designed to answer questions such as:

  • Does stress alter a distribution of Type 1 and/or Type 2 T-cells?
  • Does stress affect a secretion of Type 1 and/or Type 2 cytokines in cell culture?
  • Are any changes that occur neuro-endocrine induced or modulated?


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  • Keywords
    Immunity
    Immune system
    Immunity, cellular
    Cytokines

    Data Information
    Data Availability
    Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

    Parameters
    Cytokine mRNA
    Cytokine secreting T cells
    Cytokines
    Distribution of T cell subsets
    Hydrocortisone
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    Mission/Study Information
    Mission Launch/Start Date Landing/End Date Duration
    STS-106 09/08/2000 09/20/2000 12 days
    STS-112 10/07/2002 10/18/2002 11 days

    Additional Information
    Co-Investigators
    Managing NASA Center
    Johnson Space Center (JSC)
    Responsible NASA Representative
    Johnson Space Center LSDA Office
    Project Manager: Pamela A. Bieri
    Institutional Support
    National Aeronautics and Space Administration (NASA)
    Russian Space Agency (RSA)