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EXPERIMENT INFORMATION

Protein Expression in Salivary Glands: Effects of Extended Space Flight (ARC00XX62)
Principal Investigator
Research Area:
Developmental biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: B6.SJL-Ptprca Pepcb/BoyJ (002014)

Description
OBJECTIVES:
Physiological responses to environmental stress such as travel in space alter cellular signal processing of hormone action, and are reflected in saliva. These secretory proteins have been identified using biochemical tests and histologic analyses. The earlier studies were carried out using rat tissues whereas in the present missions mice were used.

The initial aim was to determine if the same responses occur in both animal models and to test the hypothesis that regulation of specific secretory protein expression is altered by space flight. The overall objective is to design biochemical tests to measure physiologic responses using biomarkers in saliva as indices. The ease of collecting saliva instead of blood and urine during space flight will make it possible to measure hormone changes experienced by Astronauts and Cosmonauts in microgravity.


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Publications
Mednieks, M.; Khatri, A.; Rubenstein, R.; Burleson, J.; and Hand, A.R.: Microgravity alters the expression of salivary proteins. Oral Health Dental Management, vol. 13, no. 2, 2014, pp. 211-216. pubmed.gov

Dagdeviren D, Beallias J, Khan I, Mednieks MI, Hand AR. Response of the mouse sublingual gland to spaceflight. Eur J Oral Sci. 2018 Jul 9. pubmed.gov [DOI]

Mednieks MK, Hand AR. Oral tissue responses to travel in space. In. Space Medicine. London: InTechOpen, 2019 Jun 14 [Online First]. p. 1-26. [DOI]

Keywords
Cytological techniques
Gene expression
Histological Techniques
Immunohistochemistry
Microscopy, electron
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

NASA GeneLab Data

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
PMA
STS-131 04/05/2010 04/20/2010 15 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
08/01/2009
Proposal Source
NNH07ZTT001N