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Regional Arterial Remodeling Induced by Microgravity (ARC00XX121)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: B6.SJL-Ptprca Pepcb/BoyJ (002014)

It is now evident that the shift of fluid toward the head and the unloading of postural muscles induced in the rodent hindlimb unloading model and during exposure to microgravity, alter the mechanical forces exerted on resistance arteries, the vessels responsible for regulating tissue blood flow and arterial blood pressure. Tail suspension in rats can lead to atrophy of these peripheral arteries and a reduced ability to vasoconstrict and maintain normal blood pressure.

The purpose of this proposal is to determine whether the fluid shifts and reduced activity of postural muscles induced by microgravity similarly alter rodent arterial vessel structure and some key cellular signaling pathways: does space flight result in smooth muscle atrophy of skeletal muscle and mesenteric arteries.

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Behnke, B.J.; Stabley, J.N.; McCullough, D.J.; Davis, R.T.; Dominguez, J.M.; Muller-Delp, J.M.; and Delp, M.D.: Effects of Spaceflight and Ground Recovery on Mesenteric Artery and Vein Constrictor Properties in Mice. FASEB Journal, vol. 27, no. 1, Jan. 2013, pp. 399–409.

Ghosh P, Stabley JN, Behnke BJ, Allen MR, Delp MD. Effects of spaceflight on the murine mandible: Possible factors mediating skeletal changes in non-weight bearing bones of the head. Bone. 2016 Feb;83:156-61.

Stabley, J.N.; Dominguez, J.M. 2nd; Dominguez, C.E.; Mora Solis, R.R.; Ahlgren, J.; Behnke, B.J.; Muller-Delp, J.M.; and Delp, M.D.: Spaceflight reduces vasoconstrictor responsiveness of skeletal muscle resistance arteries in mice. Journal of Applied Physiology, vol. 113, no. 9, Nov. 2012, pp. 1439-1445.

Bone resorption
Bone density
Gene expression regulation

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

NASA GeneLab Data

Expression, mRNA, RyR-2 mouse, real-time PCR (RT-PCR).
Expression, mRNA, RyR-3, mouse, real-time PCR (RT-PCR).
Expression, mRNA, SERCA2b, mouse, real-time PCR (RT-PCR).
Mass, Whole body
Morphometry, lumen diameter, cerebral resistance arteries, mouse, video microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-131 04/05/2010 04/20/2010 15 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source