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Gene expression alterations in articular cartilage, skeletal muscle and skin exposed to microgravity (ARC00XX93)
Principal Investigator
Research Area:
Bone and calcium physiology
Cell and molecular biology
Muscle physiology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6J

Our overall objective is to investigate alterations in gene expression in articular cartilage, skeletal muscle and skin exposed to microgravity. Our data from STS-131 animals demonstrate that in cartilage, muscle and skin, genes that respond to different types of common stresses such as oxidative stress and genotoxic stress are also upregulated under conditions of microgravity. This is a completely novel finding and may explain some of the tissue level effects of microgravity reported, such as muscle atrophy. We hypothesize that one effect of microgravity in these tissues is the activation of stress response genetic networks, and this has effects on cell proliferation and tissue maintenance.

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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-135 07/08/2011 07/21/2011 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source