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EXPERIMENT INFORMATION

Bone Remodeling under Differential Gravitational Environments (80NSSC19K0431)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
OBJECTIVES:
Our long-term goal is to protect the skeletal health of astronauts in space environments so they can perform their mission operations and retain their quality of life upon return to Earth. The objective of the current proposal is to determine the effects of microgravity and partial microgravity on bone remodeling, as well as evaluate hypergravity as a countermeasure for microgravity-induced bone loss. Our central hypothesis is that simulated microgravity (Space 0 g) and partial microgravity (Mars 1/3 g, Moon 1/6 g) will impair bone remodeling and that hypergravity will mitigate microgravity-induced bone loss. The rationale for this proposal is the fact that microgravity and partial microgravity cause bone loss by reducing mechanical stresses on bone. Therefore, the application of periodic hypergravity will restore normal bone stresses thereby rescuing physiological remodeling. Further study will also look at recovery rate in different microgravity conditions with and without periodic hypergravity exposure.


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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
1/31/2019
Proposal Source
2016-17 Space Biology (ROSBio) NNH16ZTT001N-FG. App G: Flight and Ground Space Biology Research