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EXPERIMENT INFORMATION

Sensitivity Modulation of Different T-Cells Activation Pathways by Microgravity (PADIAC) (ARC00XX59)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Homo sapiens Species: Human Strain: T-cells

Description
OBJECTIVES:

Mammalian cells subjected to conditions of simulated microgravity on ground as well as to space flight conditions are showing alterations in their structure and function. Changes in proliferation, differentiation and genetic expression have been demonstrated in several types of cells. Among the mammalian cells, the cells of the immune system, in particular, are severely affected by the space environment. Especially T-lymphocytes are altered in their activation process. Changes in growth rate, cytokine production, locomotion, gene expression and protein kinase C (PKC) distribution have been observed on Space Shuttle flights. The main objectives of this proposal are to further investigate, using several activators, the genetic expression of the co-stimulatory transduction pathway mediated by the CD28, to assess whether the IL-1 receptor is involved in the inhibition of the activation, to see if the activation is also restored in space as it is in simulated microgravity using anti-CD3/IL-2 and to determine which genes are than expressed under these special conditions.


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Publications
Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M.. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Jul 2. pubmed.gov

Grenon, S. M., Jeanne, M., Aguado-Zuniga, J., Conte, M. S., & Hughes-Fulford, M. (2013). Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules. Scientific Reports, 3, 1494. http://doi.org/10.1038/srep01494 pubmed.gov [DOI]

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 25 09/24/2010 11/25/2010 31 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source