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Use of dietary histidine to counteract lymphatic and mucosal immune dysfunction due to space dysbiosis (80NSSC19K0438)
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6

The objectives of this ROSBio New Investigator Award project are to determine what impact the shift in the gut microbiome has on the function of the lymphatic and immune systems of the gastrointestinal tract. We will also determine if the restoration of a key metabolite, histidine, to normal levels alleviates the observed changes.

Determining the impact of the space flight microbiome on intestinal physiology and immunology is critical to understanding future risks that may impact human space exploration. Additionally development of a countermeasure to mitigate these issues is also necessary. This proposal addresses both of these critical issues utilizing a technique that has not yet been employed in the field of space biology.

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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2016-17 Space Biology (ROSBio) NNH16ZTT001N-FG. App G: Flight and Ground Space Biology Research