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Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Microgravity and Countermeasure Development (80NSSC19K0432)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6

Skeletal muscles are dynamic mechanical and metabolic machines that drive body movement and energy expenditure. Skeletal muscles are dynamic tissues that can adapt quickly to alterations in mechanical unloading by altering their mass and muscle fiber cross-sectional area. Skeletal muscle strength and endurance are essential to the health, well-being, and performance of astronauts during spaceflight and upon return to a gravitational environment. The mechanical unloading due to the microgravity (#G) of spaceflight causes muscle fiber atrophy and fiber-type shift of postural muscles in the lower extremities and flexors in the upper extremities. Microgravity also increases the risk of skeletal muscle damage, weakness, and thus the risk of injury upon reloading (e.g., EVAs, Mars).

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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2016-17 Space Biology (ROSBio) NNH16ZTT001N-FG. App G: Flight and Ground Space Biology Research