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NASA Biochemical Profile Project (Biochem_Profile)
Principal Investigator
Research Area:
Biomedical countermeasures
Clinical medicine
Species Studied
Scientific Name: Homo sapiens Species: Human

The operation of the Biochemical Profile Project will allow a rapid response to research scientists requesting flight research data investigating effects of microgravity on human physiology and to evaluate the effectiveness of countermeasures ensuring the health and performance of humans during and after space flight. Human physiological systems work together and the establishment of this biochemical profile will provide a resource enabling the recognition of interactions through a cross-discipline approach.

The National Aeronautics and Space Administration (NASA) Human Research Program (HRP) develops, conducts, and delivers research findings and countermeasures that will maintain the health and safety of crews aboard the International Space Station (ISS) and future exploration class missions. Research operations are conducted during space flight on the ISS including the collection of human physiological samples and their return to Earth for analysis. These operations include the areas of clinical medicine, cardiovascular, bone and muscular systems, immunology, endocrinology, and urology. To support these objectives, the Biochemical Profile Project will be instituted to strategically support these investments to meet the challenges of human reseearch.

Blood and urine are commonly used to assess an astronaut's health as well as conduct research in physiological disciplines by measuring key biomarkers found in these fluids. This project will collect, process and store blood and urine samples obtained during the preflight, inflight and postflight phases of ISS missions and maintain a database of results from the analysis of these samples. A database of these samples will provide supporting evidence to scientists by providing metabolic profiles of the effects of space flight on human physiology.

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Data Information
Data Availability
Archiving in Progress. Some restricted access data exist for this experiment.
Data Sets+ Request data

2 methylcitric acid
3 methylhistidine
4 pyridoxic acid
8 hydroxy 2 deoxyguanosine
8 iso prostaglandin F2a
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 37 09/10/2013 11/10/2013 61 days
Expedition 38 11/10/2013 03/10/2014 120 days
Expedition 39 03/10/2014 05/13/2014 64 days
Expedition 40 05/13/2014 09/10/2014 133 days
Expedition 41 09/10/2014 11/09/2014 29 days
Expedition 42 11/10/2014 03/11/2015 121 days
Expedition 43 03/11/2015 06/10/2015 91 days
Expedition 44 06/10/2015 09/11/2015 93 days
Expedition 45 09/11/2015 12/11/2015 91 days
Expedition 46 12/11/2015 03/02/2016 82 days
Expedition 47 03/02/2016 06/18/2016 108 days
Expedition 48 06/18/2016 09/06/2016 80 days
Expedition 49 09/06/2016 10/30/2016 54 days
Expedition 50 10/28/2016 04/09/2017 164 days
Expedition 51 04/09/2017 06/02/2017 55 days
Expedition 52 06/02/2017 09/02/2017 92 days
Expedition 53 09/02/2017 12/14/2017 102 days
Expedition 54 12/14/2017 02/27/2018 75 days
Expedition 55 02/27/2018 06/03/2018 96 days
Expedition 56 06/03/2018 10/04/2018 123 days
Expedition 57 10/04/2018 12/20/2018 77 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Proposal Date
Proposal Source
Internal Project