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Clinical Immunology Study - European Collaboration (ESA_CIS)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Homo sapiens Species: Human

Current flight studies onboard the International Space Station (ISS) are addressing the knowledge gap regarding the status of the immune system during space flight. These studies are identifying consistent parameters which are the basis of in-flight immune dysfunction. They are also defining an appropriate monitoring strategy for in-flight immune changes. However, a knowledge gap remains regarding the clinical relevance of space flight-associated immune dysregulation. Transient immune changes may occur without clinical risk, or persistent changes may result in specific risks for adverse clinical events. A collaborative invitation was extended for NASA to participate in European clinical studies. NASA participation consisted of several high-priority immune and viral assays (based on current flight data), allowed immune monitoring similar to flight studies. Although the new ESA clinical study is focused on specific adverse clinical outcomes (intensive care unit, sepsis), participation does afford an economical opportunity to, for the first time, begin correlating immune changes with specific adverse clinical outcomes.

This study had the following specific aims:

  1. Assessment and understanding of immune system changes associated with specific adverse clinical events.
  2. Assessment and understanding of latent virus reactivation associated with specific adverse clinical events.

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Feuerecker M, Sudhoff L, Crucian B, Pagel JI, Sams C, Strewe C, Guol A, Schelling G,. Briegel J, I. Kaufmann I, and Choukèr A. Early immune anergy towards recall antigens and mitogens in patients at onset of septic shock. 2018. Scientific Reports v8, 1754. [DOI]

Immunity, cellular

B-cell cytokine production patterns
IFNg+ CD4+ T cells
IFNg+ CD8+ T cells
Interleukin 1 (IL-1)
Interleukin 10 (IL-10)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source