The Cellular Profile Test Battery is one of nine Spaceflight Standard Measures conducted on International Space Station (ISS) crewmembers. Spaceflight Standard Measures are a set of core measurements, representative of many of the risks experienced by astronauts before, during, and after spaceflight. The purpose of this project is to populate a repository with data that enables high-level monitoring of countermeasure effectiveness and meaningful interpretation of health and performance outcomes. These standard measures will support future, hypothesis-driven research that enables planetary missions by providing an optimized minimal set of measures captured from all ISS crewmembers until the end of the ISS program. These measures will be available to other studies under data sharing agreements as well as undergo analysis for trends in the astronaut population.
The Cellular Profile battery of tests uses small volumes of ambient blood and liquid saliva samples. These samples encompass both innate immunity (nonspecific defense mechanisms that come into play immediately or within hours of an antigen’s appearance in the body) and adaptive immunity (antigen-specific responses that acquire after prior exposure and recruit within hours or days of re- exposure).
Blood and saliva samples will be collected from subjects pre-, in- and post-flight under three mission scenarios: short duration (up to 105 days flight days), standard duration (between 105 to 240 flight days), and long duration (greater than 240 days).
Scheduled days of collection are as follows:
Short Duration Mission:
The Spaceflight Standard Measures project is not a hypothesis-driven study, but rather a project to create a collection of ISS data made available to future researchers and for trend analysis. As such, there are no specific hypotheses, outcome measures, or statistical analyses associated with the skeleton of the project. The project will capture a "snapshot" of optimized data that can be investigated by researchers in the future