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EXPERIMENT INFORMATION

Sensorimotor Predictors of Postlanding Functional Task Performance (SM_Postlanding_FTP)
Principal Investigator
Research Area:
Radiation Effects Team
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Astronauts experience sensorimotor disturbances during the initial exposure to microgravity and during the re-adaptation phase following a return to an earth-gravitational environment. These alterations may disrupt the ability to perform mission critical functional tasks requiring ambulation, manual control and gaze stability. Interestingly, astronauts who return from space flight show significant inter-subject variations in their abilities to readapt to a gravitational environment. The ability to predict the manner and degree to which each individual astronaut will be affected would improve the effectiveness of countermeasure training programs designed to enhance sensorimotor adaptability.

This project will characterize a set of predictive measures that include: 1) behavioral tests to assess sensory bias and adaptability; 2) imaging to determine individual brain morphological features; 3) genotype markers for genetic polymorphisms that play a role in the neural pathways underlying sensorimotor adaptation. These behavioral, brain morphological/functional and genomic measures will be significantly correlated with individual differences in sensorimotor adaptability (SA) after long-duration space flight. Information from this study will help in the design of sensorimotor adaptability training countermeasures that may be customized for each crewmember’s individual characteristics.

Investigators are conducting a retrospective study using data from relevant ongoing/completed space flight studies. They will leverage data collected from the following long-duration space flight studies: Physiological Factors Contributing to Postflight Changes in Functional Performance (Functional Task Test) (FTT); Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, Neural Bases (NeuroMapping); Postural equilibrium control evaluation as a Medical Requirement; and Recovery of Functional Performance Following Long Duration Space Flight (Field_Test). Participants in the space flight study will be invited back to enable investigators to obtain the proposed predictive behavioral and genomic measures.

This study has the following specific aims:

  1. Determine whether baseline individual sensory biases and capabilities for strategic and plastic-adaptive responses predict both change and also the ability to re-adapt sensorimotor and functional performance after long-duration space flight.
  2. Determine if baseline brain morphological metrics predict both change and also the ability to re-adapt sensorimotor and functional performance after long-duration space flight.
  3. Determine if genetic markers predict both change and also the ability to re-adapt sensorimotor and functional performance after long-duration space flight.


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Keywords
Performance
Vision
Adaptation, sensorimotor

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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
Body kinematics
Brain-derived neurotrophic factor (BDNF)
Catechol-O-methyltransferase (COMT)
Dopamine receptor D2 (DRD2
Equilibrium score
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
01/01/2019
Proposal Source
Directed Research