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EXPERIMENT INFORMATION

Atriopeptin in Atria and Plasma of Rats Orbited Aboard NASA Spacelab-3 for Seven Days (SL3 BSP3)
Principal Investigator
Research Area:
Cardiovascular physiology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Atriopeptins are of interest in space flight due to their putative involvement in the adjustment of astronauts to the cephalad shift of body fluid experienced in orbital flight. This shift of some two liters of fluid is thought to stimulate right atrial stretch receptors, resulting in the release of atriopeptins which cause natriuresis and diuresis by direct action on the kidney, inhibition of aldosterone and vasopressin secretion, and by dilation of large vessels which further enhances central pooling of blood. In this study, atriopeptin (AP-3) was examined in the atria and plasma of space-flown rats.


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Publications
Inge WH, Hartle DK. Atriopeptin (AP-3) in Atria and Plasma of Rats Orbited Aboard NASA Spacelab (SL3) for seven days. Abstract S-231; Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls (NY); 1985:S231

Inge WH, Hartle DK. Atriopeptin (AP-3) in atria and plasma of rats orbited aboard NASA Spacelab (SL3) for seven days; Abstract 83.27; 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4):380.

Inge WH, Hartle DK. Atriopeptin (AP-3) in Atria and Plasma of Rats Orbited Aboard NASA Spacelab (SL3) for seven days; Physiologist 1985; 28(6 Suppl):S231-2.

Keywords
Atrial natriuretic factor (ANF)
Fluid shifts

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Atriopeptin (AP-3), atria, ventricular apex, heart, rat, radioimmuno- assay,
Content, Atriopeptin (AP-3), plasma, rat, radioimmuno- assay

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
Vivarium control
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