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Effect of Flight in Mission SL-3 on Cytokine Production by Rats (SL3 BSP4)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley


Several lines of evidence suggest that there may be compromises of immune responses in humans or experimental animals exposed to weightless conditions during space flight, or maintained in hypodynamic, hypokinetic, antiorthostatic models simulating some aspects of weightlessness. Among those immune responses and defenses possibly altered in such conditions is the cytokine system. The present study was carried out to determine the effects of a period of weightlessness on interferon (IFN) and interleukin-3 (IL-3) production by rats.

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Sonnenfeld G, et al. Effects of Antiorthostatic Suspension and Spaceflight on Interferon Production and Immunity to Viruses. Space Life Science Symposium: Three Decades of Life Science Research in Space; 1987 June 21-26; Washington, D.C. :116-117.

Sonnenfeld G, Miller ES. The Role of Cytokines in Immune Changes Induced by Spaceflight. Journal of Leukocyte Biology 1993; 54(3):253-258.

Immune system

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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