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EXPERIMENT INFORMATION

Microprobe Analyses of Epiphyseal Plates from Spacelab 3 Rats (SL3 BSP7)
Principal Investigator
Research Area:
Skeletal physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Ultrastructural studies of epiphyseal plates from young rats flown aboard Cosmos 1129 showed that production and mineralization of matrix vesicles were delayed in flight rats. Also, the matrix of metaphyseal trabeculae contained fewer collagen fibers than did the matrix of ground controls, and the collagen was less mature as shown by smaller fiber size and lack of banding. A comprehensive analysis of plate and zone height was not carried out but no apparent difference was seen in height of zones or numbers of cells per zone. This study was to determine if differences in bone matrix formation could be observed after seven days in microgravity.


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Publications
Duke J, et al. Growth and Differentiation of Mammalian Embryonic Tissue Exposed to Hypergravity In Vivo and In Vitro. Physiologist 1985; 28(6 Suppl):S77-8.

Duke J, et al. Microprobe Analysis of Epiphyseal Plates from Spacelab 3 rats. Abstract S-217. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Duke J, Janer L, Campbell M, et al. Microprobe Analysis of Epiphyseal Plates from Spacelab 3 rats. Abstract 83.19. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4):378.

Duke J, Janer L, Campbell M, Morrow J. Microprobe Analysis of Epiphyseal Plates from Spacelab 3 rats. Physiologist 1985; 28(6 Suppl): S217-8.

Duke J, Montufar -Solis D. Spaceflight Induced Changes in Rat Growth Plates. Bone and Mineral Research 1989; 4(1):S410.

Duke, J. and D. Montufar-Solis: Proteogrlycan Granules in Growth Plates of Spacelab-3 Rats. Chemistry and Biology of Mineralized Tissues, Proceedings of the Third International Conference on the Chemistry and Biology of Mineralized Tissues, Chatham, Mass., October 16-21, 1988, M.J. Glimcher and J.B. Lian, eds. Gordon and Breach, 1989, p. 836.

Montufar -Solis D, Duke PJ. Effect of Strain, Diet and Housing on Rat Growth Plates: a Cosmos '87-Spacelab-3 comparison. Physiologist 1991; 34(1 Suppl):S183-4.

Montufar -Solis D, Duke J. Altered Distribution of Matrix Vesicles Sizes in Spacelab-3 rats. American Society for Gravitational and Space Biology (ASGSB) Bulletin 1989; 3(1):113.

Montufar -Solis D, Duke J. Changes in Rat Growth Plates Due to Strain, Diet and Housing. American Society for Gravitational and Space Biology (ASGSB) Bulletin 1989; 3(1):114.

Montufar -Solis D, Duke J. Effect of Simulated Spaceflight on Tibial and Epiphyseal Plates. American Society for Gravitational and Space Biology (ASGSB) Bulletin 1988; 1:34.

Keywords
Cell differentiation
Bone matrix
Bone mineralization
Epiphyses

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, bone mineralization, calcium, tibia, rat, Microprobe analysis, freeze-substitution
Content, bone mineralization, magnesium, tibia, rat, Microprobe analysis, freeze-substitution
Content, bone mineralization, phosphorus, tibia, rat, Microprobe analysis, freeze-substitution
Content, bone mineralization, potassium, tibia, rat, Microprobe analysis, freeze-substitution
Content, bone mineralization, sodium, tibia, rat, Microprobe analysis, freeze-substitution
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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