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EXPERIMENT INFORMATION

Morphologic and Histochemical Studies of Bone Cells from SL-3 Rats (SL3 BSP9)
Principal Investigator
Research Area:
Skeletal physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Non-weight bearing or hypogravity conditions are known to result in skeletal loss in the long bones. The mechanism is unknown but one hypothesis suggests that the lack of mechanical force or stress on the bone results in reduced osteoblastic activity and thus reduced new bone formation. The objectives here were to investigate the cellular activity of the bone forming cells, the osteoblast, in animals exposed to seven days of microgravity.


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Publications
Doty SB, Holton EM. Alterations in Bone Forming Cells Due to Reduced Weight Bearing. Physiologist 1984; 27 Suppl: S81-S82.

Doty SB. Morphologic and Histochemical Studies of Bone Cells From SL-3 rats. Abstract 83.23. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4): 379.

Doty SB. Morphologic and Histochemical Studies of Bone Cells From SL-3 rats. Abstract S-225. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Doty SB. Morphologic and Histochemical Studies of Bone Cells From SL-3 rats. Physiologist 1985; 28(6 Suppl):S225-S226.

Keywords
Bone and bones
Bone development
Osteoblasts
Cell physiology

Data Information
Data Availability
Archiving in Progress. Some data exist for this experiment.
Data Sets+ View data

Parameters
Activity, enzymic, Alkaline phosphatase, calvaria, bone, rat, Histochemical, cytochemical, microscopic (OD units)
Activity, enzymic, Alkaline phosphate, tibia, bone, rat, Histochemical, cytochemical, microscopic (OD units)
Activity, enzymic, Dipeptidase, osteoblasts, calvaria, bone, rat, Assay (intracellular) (enzyme units)
Activity, enzymic, Dipeptidase, osteoblasts, tibia, bone, rat, Assay (intracellular) (enzyme units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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