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EXPERIMENT INFORMATION

Response of Amino Acids in Hindlimb Muscles to Recovery from Hypogravity and Unloading by Tail-Cast Suspension (SL3 BSP11)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Previous work has shown that certain amino acids undergo marked changes in the soleus muscle in response to unloading by tail-cast hindlimb suspension. In light of the many changes in muscle amino acids in response to decreased use through unloading, it seemed important to make similar measurements in muscles subjected to unloading by hypogravity. The effect of microgravity on the amino acid response in muscle tissue in rats was investigated and the use of the suspension model as a substitute for hypogravity was evaluated.


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Publications
Jaspers SR, et al. Biochemical Response to Chronic Shortening in Unloaded Soleus Muscle. Journal of Applied Physiology 1985; 59:1159-63.

Jaspers SR. Metabolic Responses of Skeletal Muscle to Hypokinesia/ Hypodynamia (Atrophy, Amino Acid, Protein Turnover). Dissertation Abstracts 1985; 45:3802B.

Tischler ME, et al. Responses of Amino Acids in Hindlimb Muscle to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Abstract S-191. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Tischler ME, Henriksen EJ, Jacob S, Cook PH. Responses of Amino Acids in Hindlimb Muscle to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Physiologist 1985; 28(6 Suppl):S191-2.

Tischler ME, Henriksen EJ, Jacon S, Cook PH. Responses of Amino Acids in Hindlimb Muscle to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Abstract 83.5. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4):376.

Tischler, Marc E. and Jaspers, Stephen R. Synthesis of Amino Acids in Weight Bearing and Non-weight Bearing Leg Muscles of Suspended Rats. The Physiologist, v.28, no.6, Suppl., 1985 S-155 to S-156. [NTRS]

Tischler, ME, et al. Responses of Skeletal Muscle to Unloading - A Review. The Physiologist, v.28, no.6, Suppl., 1985, S-13 to S-14. pubmed.gov

Keywords
Amino acids
Aspartic acid
Glutamic acid
Malate dehydrogenase (MDH)
Muscles
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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
Content, Aspartate, soleus, muscle, rat, Fluorometric analysis (nmol/mg)
Content, Glutamate, soleus, muscle, rat, Fluorometric analysis (nmol/mg)
Content, Glutamine, soleus, muscle, rat, Fluorometric analysis (nmol/mg)
Content, Malate, soleus, muscle, rat, Fluorometric analysis (nmol/mg)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
Tail suspension
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