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EXPERIMENT INFORMATION

Muscle Protein and Glycogen Responses to Recovery from Hypogravity and Unloading by Tail-Cast Suspension (SL3 BSP12)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Previous studies in this lab using the tail-cast hindlimb suspension model have shown that there are specific changes in protein and carbohydrate metabolism in the soleus muscle as a response to unloading. Also, fresh tissue tyrosine and its in vitro release from the muscle are increased in the unloaded soleus, indicating that this condition causes a more negative protein balance. This study was to investigate the effect of microgravity and suspension on protein and carbohydrate metabolism in a number of rat hindlimb muscles.


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Publications
Henriksen EJ, et al. Muscle Protein and Glycogen Responses to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Abstract S-193. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Henriksen EJ, Tischler ME, Jacob S, Cook PH, et al. Muscle Protein and Glycogen Responses to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Abstract 83.6. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4):376.

Henriksen EJ, Tischler ME, Jacob S, Cook PH. Possible Mechanism for Changes in Glycogen Metabolism in Unloaded Soleus Muscle. Physiologist 1985; 28(6 Suppl): S131-2.

Tischler ME, et al. Muscle Protein and Glycogen Responses to Recovery from Hypogravity and Unloading by Tail-Cast Suspension. Physiologist 1985; 28(6 Suppl):S193-4.

Keywords
Amino acids
Carbohydrates
Glycogen
Metabolism
Muscle, skeletal
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Glycogen, in muscle (soleus, gastroc, edl, tibialis ant, plantaris), rat, KOH, assay
Content, Protein, extensor digitorum longus, muscle, rat, Spectrophotometry
Content, Protein, gastrocnemius, muscle, rat, Spectrophotometry
Content, Protein, plantaris, muscle, rat, Spectrophotometry
Content, Protein, soleus, muscle, rat, Spectrophotometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
Tail suspension
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