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Examining the Effects of Spaceflight on GSK3 Activation in Murine Muscle (ARC00XX224)
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6

It is well established that spaceflight leads to muscle and bone loss, and the promising future of long-term spaceflight missions heightens the need to develop interventions that maintain musculoskeletal health. On earth, the deleterious effects observed on muscle and bone with spaceflight mimics the effects observed with human aging (ie. osteoporosis and sarcopenia). Therefore, examining the cellular mechanisms that contribute to muscle and bone loss will help in directing the development of mitigation strategies not only for spaceflight but also for aging on earth. Glycogen synthase kinase 3 (GSK3) is an enzyme that has been implicated in several other musculoskeletal conditions. Thus, our proposed research seeks to examine the effects of spaceflight on GSK3 activity in murine soleus muscle and bone while correlating it with markers of muscle proteolysis, oxidative metabolism, and bone mineral density, structure and strength. The specific aims and corresponding hypotheses of our proposal are listed below. For our muscle analyses, we propose to examine the effects of spaceflight on the soleus muscle, given that this muscle is primarily affected by microgravity.

Aim 1: Examining GSK3 activation in muscle and bone samples collected from male C57BL/6 mice from the RR9 mission
Aim 2: Examining GSK3 activation in muscle samples collected from female C57BL/6 from the RR1 mission

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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
SpaceX_12 08/14/2017 09/16/2017 33 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source