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EXPERIMENT INFORMATION

Effects of Weightlessness on Neurotransmitter Receptors in Selected Brain Areas (SL3 BSP18)
Principal Investigator
Research Area:
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

A number of physiological responses to the microgravity environment have been previously described. For example, temperature regulation, fluid volume and water intake, calcium metabolism and the neuromuscular control of movement are altered under microgravity. Such adaptations to microgravity may be mediated by corresponding changes in brain neurotransmitter dynamics. This study examined the effect of weightlessness on the neurotransmitter receptors in selected areas of the brain of space-flown rats.


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Publications
Miller JD, et al. Effects of Weightlessness on Neurotransmitter Receptors in Selected Brain Areas. Abstract S-203. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY)

Miller JD, McMillen BA, Murakami DM, McConnaughey MM, Williams HL, Fuller CA. Effects of Weightlessness on Neurotransmitter Receptors in Selected Brain Areas. Abstract 83.12. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo (NY) Physiologist 1985; 28(4):377.

Miller JD, McMillen BA, Murakami DM, McConnaughey MM, Williams HL, Fuller CA. Effects of Weightlessness on Neurotransmitter Receptors in Selected Brain Areas. Physiologist 1985; 28(6 Suppl):S203-4.

Keywords
Hippocampus
Orientation
Motor cortex
Neurotransmitters
Brain

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Dopamine receptors, hippocampus, brain, rat, Standard receptor assay
Count, Dopamine receptors, posterior cortex, brain, rat, Standard receptor assay
Count, Gamma-aminobutyric acid (GABA) receptors, hippocampus, brain, rat, Standard receptor assay
Count, Gamma-aminobutyric acid (GABA) receptors, posterior cortex, brain, rat, Standard receptor assay
Count, Noradrenaline receptors, hippocampus, brain, rat, Standard receptor assay
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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