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EXPERIMENT INFORMATION

Reduction of the Spermatogonial Population in Rat Testes Flown on Spacelab 3 (SL3 BSP20)
Principal Investigator
Research Area:
Developmental biology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Testes have been shown to be affected by space flight, immobilization and hypergravity, and are extremely sensitive to cosmic radiation. The site of action of these various environmental changes and the mechanisms by which they interfere with both spermatogenesis and steroidogenesis requires further investigation. This study examined the effects of space flight on spermatogonia in rat testes

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Publications
Philpott DE, et al. Reduction of Spermatogonia and Testosterone in Rats Flown on Spacelab-3. Proceedings of the Electron Microscopy Society of America, 44th Annual Meeting; 1986 Aug 10-15; Albuquerque(NM):248-9.

Philpott DE, et al. Reduction of the Spermatogonial Population in Rat Testes Flown on Spacelab-3. Abstract S-211. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Philpott DE, et al. Response of the Seminiferous Epithelium of the Mouse Exposed to Low Dose High Energy (HZE) and Electromagnetic Radiation. Scanning Electron Microscopy 1983; III:1345.

Philpott DE, Sapp W, Williams C, Stevenson J, Black S, Corbett R. Reduction of the Spermatogonial Population in Rat Testes Flown on Spacelab-3. Abstract 83.16. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY): Physiologist 1985; 28(4):378.

Philpott DE, Sapp W, Williams C, Stevenson J, Black S, Corbett R. Reduction of the Spermatogonial Population in Rat Testes Flown on Spacelab-3. Physiologist 1985; 28(6 Suppl):S211-12.

Keywords
Cell count
Cells
Radiation
Spermatogenesis
Stress
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Spermatogonia, testes, rat, Histochemistry, microscopy
Weight, tissue (organ), Testes, rat, Balance (CGS units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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