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EXPERIMENT INFORMATION

Hepatic Enzymes of Sphingolipid and Glycerolipid Biosynthesis in Rats from Spacelab 3 (SL3 BSP23)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Lipid metabolism is a major function of liver, which synthesizes these molecules for membranes, bile and lipoproteins. The activity ratio of serine palmitoyltransferase (SPT) and glycerol 3-phosphate acyltransferase (GPAT), the initial enzymes of sphingolipid and glycerolipid synthesis, is one determinant of tissue lipid composition. Since changes have been observed in some of the enzymes of lipid metabolism in livers from rats under weightless conditions aboard Cosmos, the activities of these key enzymes, SPT and GPAT, were studied in the rats of Spacelab-3.


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Publications
Merrill AH, et al. Hepatic Function in Rats After Spaceflight: Effects on Lipids, Glycogen, and Enzymes. American Journal of Physiology 1987; 252:R222-6.

Merrill AH, Wang E, Hargrove JL. Hepatic Enzymes of Sphingolipid and Glycerolipid Biosynthesis in Rats from Spacelab-3. Abstract 83.27 . 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY):380.

Merrill AH, Wang E, Hargrove JL. Hepatic Enzymes of Sphingolipid and Glycerolipid Biosynthesis in Rats from Spacelab-3. Abstract S-229. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Merrill AH, Wang E, Hargrove JL.Hepatic Enzymes of Sphingolipid and Glycerolipid Biosynthesis in Rats from Spacelab-3. Physiologist 1985; 28(6 Suppl):S229.

Keywords
Liver
Lipids
Enzymes
Metabolism

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Glycerol 3-phosphate acyltransferase (GPAT), liver, rat, Assay (enzyme units)
Activity, enzymic, Serine palmitoyltransferase (SPT), liver, rat, Assay (enzyme units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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