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EXPERIMENT INFORMATION

Hepatic Enzyme Adaptation in Rats after Spaceflight (SL3 BSP24)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Metabolic breakdown of pharmaceutical agents, nutrients, and many hormones begins in the liver and the numerous hepatic enzymes that regulate these catabolic functions respond adaptively to environmental and biochemical changes. The ability to adapt to microgravity during prolonged space flight requires biochemical adjustments that follow changes such as increased secretion of adrenal hormones. This study was to determine whether hepatic enzyme concentrations change during space flight.


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Publications
Hargrove JL, Jones DP. Hepatic Enzyme Adaptation in Rats After Spaceflight. Abstract 83.28. 3Abstract 83.22. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY):380.

Hargrove JL, Jones DP. Hepatic Enzyme Adaptation in Rats After Spaceflight. Abstract S-230. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Hargrove JL, Jones DP. Hepatic Enzyme Adaptation in Rats After Spaceflight. Physiologist 1985; 28(6 Suppl):S230.

Keywords
Aspartate aminotransferase
Enzymes
Metabolism
Glycogen
Liver

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Aspartate aminotransferase (AST), liver, rat: Spectrophotometry
Activity, enzymic, Cytochrome b5, liver, rat: Spectrophotometry
Activity, enzymic, Cytochrome P450, liver, rat: Spectrophotometry
Activity, enzymic, Tyrosine aminotransferase, liver, rat: Spectrophotometry
Content, Glycogen, liver, rat, Anthrone reaction

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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