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EXPERIMENT INFORMATION

Plasma Renin Concentrations of Rats Orbited for 7 Days Aboard NASA Spacelab 3 (SL3 BSP25)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

There are several cardiovascular, hormonal, and neural mechanisms regulating renin secretion that may be significantly affected by the physiological adaptations to the stresses of space flight and microgravity. The renin-angiotensin-aldosterone system defends the extracellular fluid compartment and blood pressure by promoting positive sodium balance and enhancing vasoconstrictor tone. Atriopeptin III augments shifts in extracellular fluid and may cause contraction of the extracellular fluid compartment by promoting diuresis and natriuresis. This study attempted to detect an alteration in renin secretion in space-flown rats.


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Publications
Hartle DK, Inge WH. Plasma renin concentrations (PRC) of rats orbited for 7 days aboard NASA Spacelab 3. Abstract 83.30. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY): 380.

Hartle DK, Inge WH. Plasma renin concentrations (PRC) of rats orbited for 7 days aboard NASA Spacelab 3. Abstract S-233-S-234. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Hartle DK, Inge WH. Plasma Renin Concentrations (PRC) of rats orbited for 7 days aboard NASA Spacelab 3. Physiologist 1985; 28(6 Suppl):S233-4.

Keywords
Renin
Atrial natriuretic factor (ANF)
Extracellular space

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Renin, plasma, trunk blood, rat, Renin substrate conversion to angiotensin I, radioimmunoassay.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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