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EXPERIMENT INFORMATION

Microgravity Associated Changes in Pituitary Growth Hormone (GH) Cells Prepared from Rats Flown on Spacelab 3 (SL3 BSP27)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Preliminary results from a rat pituitary cell culture experiment flown on STS-8 indicated that subsequent release of growth hormone (GH) from these cells at unit gravity might be impaired relative to that from ground-based control cells. Since GH exerts control over metabolic activities and macromolecule biosynthesis in a number of target tissues, impaired GH cell function in microgravity could conceivably participate in atrophy of those targets.


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Publications
Grindeland RE, et al. Changes in Pituitary Growth Hormone Cells Prepared from Rats Flown on Spacelab 3. American Journal of Physiology 1987; 252:R209-15.

Grindeland RE, et al. Does Altered Growth Hormone Play a Role in Muscle Atrophy of Simulated Weightlessness?. Space Life Science Symposium: Three Decades of Life Science Research in Space 1987, NASA TM-108002: 82-3.

Hymer WC, et al. Microgravity Associated Changes in Pituitary Growth Hormone (GH) Cells Prepared from Rats Flown on Spacelab 3. Abstract S-197. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Hymer WC, Grindeland R, Farrington M, Fast T, Hayes C, Motter K, et al. Microgravity Associated Changes in Pituitary Growth Hormone (GH) Cells Prepared from Rats Flown on Spacelab 3. Abstract 83.9. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY): 377.

Hymer WC, Grindeland R, Farrington M, Fast T, Hayes C, Motter K, et al. Microgravity Associated Changes in Pituitary Growth Hormone (GH) Cells Prepared from Rats Flown on Spacelab 3. Physiologist 1985; 28(6 Suppl):S197-8.

Motter K, et al. Effects of Microgravity on Rat Pituitary Growth Hormone (GH) function: Comparison of Results of the SL-3 Mission with Rat "Unloading" on earth. Space Life Science Symposium: Three Decades of Life Science Research in Space 1987, NASA TM-108002: 52-3.

Kraemer WJ, Mastro AM, Gordon SE, Koziris LP, Bush JA, Volek JS, Staron RS, French DN, Sharman MJ, Jemiolo B, Deschenes MR, Hymer WC.. Responses of plasma proenkephalin peptide f in rats following 14 days of spaceflight. Aviat Space Environ Med 2004; 75:114 –7. pubmed.gov

Keywords
Pituitary hormones
Somatotropin
Metabolism
Biosynthesis

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Growth hormone cells (Somatotroph), pituitary, rat, Flow cytometry immunofluorescence

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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