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EXPERIMENT INFORMATION

Effect of Flight in Mission SL-3 on Interferon-Gamma Production by Rats (SL3 BSP4.1)
Principal Investigator
Research Area:
Immunology
Microbiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Several lines of evidence suggest that there may be compromises of immune responses in humans or experimental animals exposed to weightlessness conditions during space flight, or maintained in hypodynamic, hypokinetic, antiorthostatic models simulating some aspects of weightlessness. Among those possible immune responses and is the interferon (IFN) system. The present study was carried out to determine the effects of a period of weightlessness on IFN production by rats and to determine if the animal system could be useful in evaluating the effects of space flight on IFN.


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Publications
Gould CL, et al. Effects of Flight in Mission SL-3 on Interferon-Gamma Production by Rats. Abstract S-213. Proceedings of the Seventh Annual Meeting on the IUPS Commission on Gravitational Physiology; 1985 Oct 13-18; Niagara Falls(NY).

Gould CL, et al. Inhibited Interferon-Gamma But Normal Interleukin-3 Production from Rats Flown on the Space Shuttle. Aviation, Space, and Environmental Medicine 1987; 58(10): 983-6.

Gould CL, Williams JA, Mandel AD, Sonnenfeld G. Effects of flight in mission SL-3 on interferon-gamma production by rats. Abstract 83.17. 36th Annual Fall Meeting of the American Physiological Society; 1985 Oct 13-18; Buffalo(NY): 378.

Gould CL, Williams JA, Mandel AD, Sonnenfeld G. Effects of flight in mission SL-3 on interferon-gamma production by rats. Physiologist 1985; 28(6 Suppl): S213-4.

Sonnenfeld G, et al. Effects of Antiorthostatic Suspension and Spaceflight on Interferon Production and Immunity to Viruses. Space Life Science Symposium: Three Decades of Life Science Research in Space, 1987 June 21-26; Washington, D.C.:116-7.

Sonnenfeld G, et al. Inhibited Interferon Production after Spaceflight. Acta Microbiologia Hungaria, 1988; 35(4): 411-6.

Keywords
Interferons
Immunity
Immune system
Interferon type II

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, immune, antiviral, Interferon-gamma activity, spleen cells, rat, Assay, mouse L-929 cell (plaque reduction, titer)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51B 04/29/1985 05/06/1985 7 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Simulated flight control
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