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Mechanism of Accelerated Aging Under Microgravity (Phospho_Aging)
Research Area:
Biomedical countermeasures
Skeletal physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Serum protein fetuin-A binds calcium-phosphate to prevent the amalgamation of calcium phosphate crystals in extraosseous tissues. The resulting calciprotein particle (CCP) is implicated as a risk factor for poor health outcomes such as chronic inflammation, arteriosclerosis and chronic kidney disease. Spaceflight induced bone loss should contribute to increased levels of CCP in blood and primary urine of astronauts and is potentially a cause of accelerated aging in astronauts. This experiment has the following aims:
1. To measure biomarkers for mineral metabolism, including CCP, to compare with pre- and post-BDC levels.
2. To determine the potential role of mineral metabolism in the accelerated aging of astronauts observed during spaceflight.

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Bone density
Calcium-binding proteins

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

24 hour urine
Blood chemistry
Calciprotein particle (CCP); markers of calcium metabolism
Content, Fat, whole body, primate, Dual energy x-ray absorptiometry (DEXA)
Content; Vitamin D (1,25 dihycroxy), blood
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 63 04/17/2020 10/21/2020 187 days
Expedition 64 10/21/2020 04/16/2021 177 days
Expedition 65 04/16/2021 10/17/2021 184 days
Expedition 66 10/17/2021 03/30/2022 164 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
Japan Aerospace Exploration Agency (JAXA)
Proposal Date
Proposal Source