EXPERIMENT INFORMATION
Mechanism of Accelerated Aging Under Microgravity (Phospho_Aging)
Research Area:
Biomedical countermeasures
Skeletal physiology
Species Studied
Scientific Name: Homo sapiens Species: Human
Study Type
Description
Objectives
Serum protein fetuin-A binds calcium-phosphate to prevent the amalgamation of calcium phosphate crystals in extraosseous tissues. The resulting calciprotein particle (CCP) is implicated as a risk factor for poor health outcomes such as chronic inflammation, arteriosclerosis and chronic kidney disease. Spaceflight induced bone loss should contribute to increased levels of CCP in blood and primary urine of astronauts and is potentially a cause of accelerated aging in astronauts. This experiment has the following aims:
1. To measure biomarkers for mineral metabolism, including CCP, to compare with pre- and post-BDC levels.
2. To determine the potential role of mineral metabolism in the accelerated aging of astronauts observed during spaceflight.
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Serum protein fetuin-A binds calcium-phosphate to prevent the amalgamation of calcium phosphate crystals in extraosseous tissues. The resulting calciprotein particle (CCP) is implicated as a risk factor for poor health outcomes such as chronic inflammation, arteriosclerosis and chronic kidney disease. Spaceflight induced bone loss should contribute to increased levels of CCP in blood and primary urine of astronauts and is potentially a cause of accelerated aging in astronauts. This experiment has the following aims:
1. To measure biomarkers for mineral metabolism, including CCP, to compare with pre- and post-BDC levels.
2. To determine the potential role of mineral metabolism in the accelerated aging of astronauts observed during spaceflight.
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Keywords
Aging
Bone density
Calcium-binding proteins
Calcium
Data Availability
Archiving in progress. Data is not yet available for this experiment.
Parameters
24 hour urine
Blood chemistry
Calciprotein particle (CCP); markers of calcium metabolism
Content, Fat, whole body, primate, Dual energy x-ray absorptiometry (DEXA)
Content; Vitamin D (1,25 dihycroxy), blood
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Mission/Study Information
| Mission | Launch/Start Date | Landing/End Date | Duration |
|---|---|---|---|
| Expedition 63 | 04/17/2020 | 10/21/2020 | 187 days |
| Expedition 64 | 10/21/2020 | 04/16/2021 | 177 days |
| Expedition 65 | 04/16/2021 | 10/17/2021 | 184 days |
| Expedition 66 | 10/17/2021 | 03/30/2022 | 164 days |
Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
Japan Aerospace Exploration Agency (JAXA)
Proposal Date
Proposal Source
International